BDBM391081 2-((1R,2R)-2-fluoro-1-(3- ((2-fluoropyridin-4-yl) amino)-4-oxo-4,5-dihydro- 1H-pyrazolo[4,3-c]pyridin- 1-yl)cyclohexyl)acetonitrile (from I-19A)::US9957264, Example 5-152

SMILES F[C@@H]1CCCC[C@]1(CC#N)n1nc(Nc2ccnc(F)c2)c2c1cc[nH]c2=O

InChI Key InChIKey=YKJUCYZKVUYVKX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391081   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391081(US9957264, Example 5-152 | 2-((1R,2R)-2-fluoro-1-(...)
Affinity DataIC50: 0.0900nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391081(US9957264, Example 5-152 | 2-((1R,2R)-2-fluoro-1-(...)
Affinity DataIC50: 0.680nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent