BDBM391114 US9957264, Example 5-185::tert-butyl [5-({1-[(3S)-3- (cyanomethyl)tetrahydro- 2H-pyran-3-yl]-4-oxo-4,5- dihydro-1H-pyrazolo[4,3- c]pyridin-3-yl}amino)-1,1- dioxido-1,2-benzisothiazol- 2(3H)-yl]acetate (from I-17B)

SMILES CC(C)(C)OC(=O)CN1Cc2cc(Nc3nn(c4cc[nH]c(=O)c34)[C@]3(CC#N)CCCOC3)ccc2S1(=O)=O

InChI Key InChIKey=NSQHXILTPOSWFU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391114   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391114(US9957264, Example 5-185 | tert-butyl [5-({1-[(3S)...)
Affinity DataIC50: 0.0800nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391114(US9957264, Example 5-185 | tert-butyl [5-({1-[(3S)...)
Affinity DataIC50: 1.5nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent