BDBM391118 US9957264, Example 5-189::US9957264, Example 5-190::{(3S)-3-[3-({4-[(1R or 1S)- 1-(tert-butylamino)-2,2,2- trifluoroethyl]phenyl} amino)-4-oxo-4,5- dihydro-1H-pyrazolo [4,3-c]pyridin-1- yl]tetrahydro-2H-pyran-3- yl}acetonitrile (from I-17B. Derived from Peak A via SFC: IA column, 35% MeOH in CO2, Tr = 2.8 minutes on OBn intermediate)
SMILES CC(C)(C)NC(c1ccc(Nc2nn(c3cc[nH]c(=O)c23)[C@]2(CC#N)CCCOC2)cc1)C(F)(F)F
InChI Key InChIKey=YYKBDXVPRSJIGW-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 391118
Affinity DataIC50: 0.140nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.170nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.210nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.380nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair