BDBM391260 4-[(1-{1-[(3- chlorophenyl)carbonyl]-4- (cyanomethyl)piperidin-4-yl}- 4-oxo-4,5-dihydro-1H- pyrazolo [4,3-c]pyridin-3-yl)amino]- N,N- dimethylbenzenesulfonamide::US9957264, Example 9-14

SMILES CN(C)S(=O)(=O)c1ccc(Nc2nn(c3cc[nH]c(=O)c23)C2(CC#N)CCN(CC2)C(=O)c2cccc(Cl)c2)cc1

InChI Key InChIKey=GBERGRYOBACTTD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391260   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391260(US9957264, Example 9-14 | 4-[(1-{1-[(3- chlorophen...)
Affinity DataIC50: 0.230nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391260(US9957264, Example 9-14 | 4-[(1-{1-[(3- chlorophen...)
Affinity DataIC50: 1.96nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent