BDBM394368 N-[3-[5-chloro-2- (difluoromethoxy)phenyl]-1-[2- (dimethylamino)-1-methyl-2-oxo- ethyl]pyrazol-4-yl]pyrazolo[1,5- a]pyrimidine-3-carboxamide::US10307426, Example 10::US10307426, Example 11

SMILES CC(C(=O)N(C)C)n1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F

InChI Key InChIKey=CRDFCSQRBAYGGR-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 394368   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM394368(N-[3-[5-chloro-2- (difluoromethoxy)phenyl]-1-[2- (...)
Affinity DataKi:  0.410nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM394368(N-[3-[5-chloro-2- (difluoromethoxy)phenyl]-1-[2- (...)
Affinity DataKi:  0.580nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM394368(N-[3-[5-chloro-2- (difluoromethoxy)phenyl]-1-[2- (...)
Affinity DataKi:  0.830nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM394368(N-[3-[5-chloro-2- (difluoromethoxy)phenyl]-1-[2- (...)
Affinity DataKi:  1.26nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent