BDBM395296 N-[2-(3-Hydroxy-3-methylbutyl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide::US10308634, Example 11::US10793545, Example 11::US11897863, Compound Control BAY-1834845::US11992481, Example 11::US12006303, Example 11::US20240132473, Compound BAY-1830839

SMILES: CC(C)(CCn1cc2cc(c(cc2n1)C(C)(C)O)NC(=O)c3cccc(n3)C(F)(F)F)O

InChI Key: InChIKey=NWFPCWIBSBZRGV-UHFFFAOYSA-N

Data: 10 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 395296   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Human)	BDBM395296 (N-[2-(3-Hydroxy-3-methylbutyl)-6-(2-hydroxypropan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
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Interleukin-1 receptor-associated kinase 4 (Human)	BDBM395296 (N-[2-(3-Hydroxy-3-methylbutyl)-6-(2-hydroxypropan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a	n/a
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Interleukin-1 receptor-associated kinase 4 (Human)	BDBM395296 (N-[2-(3-Hydroxy-3-methylbutyl)-6-(2-hydroxypropan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
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Interleukin-1 receptor-associated kinase 4 (Human)	BDBM395296 (N-[2-(3-Hydroxy-3-methylbutyl)-6-(2-hydroxypropan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.70	n/a	n/a	n/a	n/a	n/a	n/a
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Interleukin-1 receptor-associated kinase 4 (Human)	BDBM395296 (N-[2-(3-Hydroxy-3-methylbutyl)-6-(2-hydroxypropan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Human)	BDBM395296 (N-[2-(3-Hydroxy-3-methylbutyl)-6-(2-hydroxypropan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
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Interleukin-1 receptor-associated kinase 1 (Human)	BDBM395296 (N-[2-(3-Hydroxy-3-methylbutyl)-6-(2-hydroxypropan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Human)	BDBM395296 (N-[2-(3-Hydroxy-3-methylbutyl)-6-(2-hydroxypropan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Human)	BDBM395296 (N-[2-(3-Hydroxy-3-methylbutyl)-6-(2-hydroxypropan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	128	n/a	n/a	n/a	n/a	n/a	n/a
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High affinity nerve growth factor receptor (Human)	BDBM395296 (N-[2-(3-Hydroxy-3-methylbutyl)-6-(2-hydroxypropan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.36E+5	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Human)	BDBM395296 (N-[2-(3-Hydroxy-3-methylbutyl)-6-(2-hydroxypropan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Human)	BDBM395296 (N-[2-(3-Hydroxy-3-methylbutyl)-6-(2-hydroxypropan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair