BDBM4016 1-methyl-2-{[1-methyl-3-(phenylcarbamoyl)-1H-indol-2-yl]disulfanyl}-N-phenyl-1H-indole-3-carboxamide::2,2 -Dithiobis( 1-methyl-N-phenyl- 1H-indole-3-carboxamide)::CHEMBL304414::dithiobis(1H-indole-3-carboxamide) deriv. 10a

SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3ccccc3n2C)c(C(=O)Nc2ccccc2)c2ccccc12

InChI Key InChIKey=PRTBWEHHMHBKER-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4016   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Auckland

LigandPNGBDBM4016(1-methyl-2-{[1-methyl-3-(phenylcarbamoyl)-1H-indol...)
Affinity DataIC50:  1.00E+4nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM4016(1-methyl-2-{[1-methyl-3-(phenylcarbamoyl)-1H-indol...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibitory concentration of the against pp60v-src tyrosine kinase obtained from v-src baculovirus-infected insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Auckland

LigandPNGBDBM4016(1-methyl-2-{[1-methyl-3-(phenylcarbamoyl)-1H-indol...)
Affinity DataIC50:  1.09E+4nMAssay Description:Inhibitory concentration compound against EFGR tyrosine kinase obtained from plasma membrane vesicles from cultured A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase transforming protein Src(Avian sarcoma virus)
University Of Auckland

LigandPNGBDBM4016(1-methyl-2-{[1-methyl-3-(phenylcarbamoyl)-1H-indol...)
Affinity DataIC50:  3.20E+3nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed