BDBM404266 ((2-Ethoxyphenyl)((2R,5R)-5-(5-(2-hydroxypropan-2-yl)isoxazol-3-yl)-2-methylpiperidin-1-yl)methanone::US10017504, 5

SMILES CCOc1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)c1cc(on1)C(C)(C)O

InChI Key InChIKey=NNVRYMAVSLEJJV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 404266   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404266(((2-Ethoxyphenyl)((2R,5R)-5-(5-(2-hydroxypropan-2-...)
Affinity DataIC50: 1.19E+3nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404266(((2-Ethoxyphenyl)((2R,5R)-5-(5-(2-hydroxypropan-2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent