BDBM412060 2-amino-6-fluoro-N-[5-fluoro-4-[4-[4-(oxetan-3-yl)piperazine-1-carbonyl]-1-piperidyl]-3-pyridyl]pyrazolo pyrimidine-3-carboxamide ::US10392391, Compound I-G-32::US10787452, Compound I-G-32::US11117900, Compound I-G-32::US11370798, Cmpd. # I-G-32::US20230271963, Compound I-G-32

SMILES: Nc1nn2cc(F)cnc2c1C(=O)Nc1cncc(F)c1N1CCC(CC1)C(=O)N1CCN(CC1)C1COC1

InChI Key: InChIKey=QAYHKBLKSXWOEO-UHFFFAOYSA-N

Data: 12 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 412060   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase ATR (Human)	BDBM412060 (US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase ATR (Human)	BDBM412060 (US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Human)	BDBM412060 (US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM412060 (US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Human)	BDBM412060 (US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Human)	BDBM412060 (US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...) Show SMILES Show InChI	GoogleScholar	UniChem		<0.150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Human)	BDBM412060 (US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...) Show SMILES Show InChI	GoogleScholar	UniChem		<0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Human)	BDBM412060 (US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...) Show SMILES Show InChI	GoogleScholar	UniChem		2.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Human)	BDBM412060 (US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...) Show SMILES Show InChI	GoogleScholar	UniChem		<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Human)	BDBM412060 (US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...) Show SMILES Show InChI	GoogleScholar	UniChem		<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Human)	BDBM412060 (US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...) Show SMILES Show InChI	GoogleScholar	UniChem		<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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ATR-interacting protein/DNA topoisomerase 2-binding protein 1/Dual specificity protein kinase CLK2/Serine/threonine-protein kinase ATR (Human)	BDBM412060 (US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...) Show SMILES Show InChI	GoogleScholar	UniChem		<20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATR-interacting protein/DNA topoisomerase 2-binding protein 1/Dual specificity protein kinase CLK2/Serine/threonine-protein kinase ATR (Human)	BDBM412060 (US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...) Show SMILES Show InChI	GoogleScholar	UniChem		<200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Human)	BDBM412060 (US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...) Show SMILES Show InChI	GoogleScholar	UniChem		505	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Human)	BDBM412060 (US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...) Show SMILES Show InChI	GoogleScholar	UniChem		505	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Human)	BDBM412060 (US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...) Show SMILES Show InChI	GoogleScholar	UniChem		505	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Human)	BDBM412060 (US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...) Show SMILES Show InChI	GoogleScholar	UniChem		550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Human)	BDBM412060 (US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...) Show SMILES Show InChI	GoogleScholar	UniChem		3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair