BDBM413305 (S)-4-(5-hydroxy-1-(5-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)pyridin-2-yl)-1H-pyrazol-4-yl)benzonitrile::US10407409, Example 352

SMILES Oc1c(cnn1-c1ccc(cn1)C(=O)N1CCC[C@H]1CN1CCCC1)-c1ccc(cc1)C#N

InChI Key InChIKey=IYTZTPFDIOGXJI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 413305   

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413305((S)-4-(5-hydroxy-1-(5-(2-(pyrrolidin-1-ylmethyl)py...)
Affinity DataIC50: 33.9nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent