BDBM417439 2-(6-{5-chloro-2- [(oxan-4-yl)amino] pyrimidin-4-yl}-1-oxo- 2,3-dihydro-1H- isoindol-2-yl)-N-[(1R)- 1,2,3,4-tetrahydro naphthalen-1-yl] acetamide::US10457669, Example 50::US11001575, Example 50

SMILES Clc1cnc(NC2CCOCC2)nc1-c1ccc2CN(CC(=O)N[C@@H]3CCCc4ccccc34)C(=O)c2c1

InChI Key InChIKey=PTAYEJOLYURCSO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 417439   

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM417439(2-(6-{5-chloro-2- [(oxan-4-yl)amino] pyrimidin-4-y...)
Affinity DataIC50: 20nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM417439(2-(6-{5-chloro-2- [(oxan-4-yl)amino] pyrimidin-4-y...)
Affinity DataIC50: 20nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent