BDBM417538 6-{5-chloro-2-[(oxan- 4-yl)amino] pyrimidin-4-yl}-2-[2- (3-methyl-1,2,3,4- tetrahydro isoquinolin-2-yl)-2- oxoethyl]-2,3- dihydro-1H-isoindol- 1-one::US10457669, Example 152::US11001575, Example 152

SMILES CC1Cc2ccccc2CN1C(=O)CN1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl

InChI Key InChIKey=FJXHUTSPZNKSML-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 417538   

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM417538(6-{5-chloro-2-[(oxan- 4-yl)amino] pyrimidin-4-yl}-...)
Affinity DataIC50: 4.40nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM417538(6-{5-chloro-2-[(oxan- 4-yl)amino] pyrimidin-4-yl}-...)
Affinity DataIC50: 4.40nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent