BDBM417559 6-{5-chloro-2-[(2,2- dimethyloxan-4- yl)amino]pyrimidin-4- yl}-2-[2-oxo-2-(1,2,3,4- tetrahydroisoquinolin- 2-yl)ethyl]-2,3-dihydro- 1H-isoindol-1-one::US10457669, Example 174::US11001575, Example 174

SMILES CC1(C)CC(CCO1)Nc1ncc(Cl)c(n1)-c1ccc2CN(CC(=O)N3CCc4ccccc4C3)C(=O)c2c1

InChI Key InChIKey=UERAFGZKHFNNGQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 417559   

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM417559(6-{5-chloro-2-[(2,2- dimethyloxan-4- yl)amino]pyri...)
Affinity DataIC50: 140nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM417559(6-{5-chloro-2-[(2,2- dimethyloxan-4- yl)amino]pyri...)
Affinity DataIC50: 140nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent