BDBM418247 (2R)-2-(6-{5-chloro-2-[(2-methyl-2H- 1,2,3-triazol-4-yl)amino]pyridin-4-yl}- 1-oxo-2,3-dihydro-1H-isoindol-2-yl)-N- [(1R)-1-[6-(4-methylpiperazin-1- yl)pyridin-2-yl]ethyl]propanamide::US10457669, Example 1018::US11001575, Example 1018

SMILES C[C@@H](NC(=O)[C@@H](C)N1Cc2ccc(cc2C1=O)-c1cc(Nc2cnn(C)n2)ncc1Cl)c1cccc(n1)N1CCN(C)CC1

InChI Key InChIKey=YBFFCYIOYOTDFN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 418247   

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418247(US10457669, Example 1018 | (2R)-2-(6-{5-chloro-2-[...)
Affinity DataIC50: 5.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418247(US10457669, Example 1018 | (2R)-2-(6-{5-chloro-2-[...)
Affinity DataIC50: 5.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent