BDBM418250 (2R)-2-(6-{5-chloro-2-[(5-methyl-1,2- oxazol-3-l)amino]pyrimidin-4-yl}-1- oxo-2,3-dihydro-1H-isoindol-2-yl)-N- [(1S)-1-(3-fluoro-5-methoxyphenyl)-2- hydroxyethyl]propanamide::US10457669, Example 1024::US11001575, Example 1024

SMILES COc1cc(F)cc(c1)[C@@H](CO)NC(=O)[C@@H](C)N1Cc2ccc(cc2C1=O)-c1nc(Nc2cc(C)on2)ncc1Cl

InChI Key InChIKey=GOTGHQVOWMZKSZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 418250   

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418250(US10457669, Example 1024 | (2R)-2-(6-{5-chloro-2-[...)
Affinity DataIC50: 2.80nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418250(US10457669, Example 1024 | (2R)-2-(6-{5-chloro-2-[...)
Affinity DataIC50: 2.80nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent