BDBM418817 N-methyl-4-({4-[({3- [methyl(methylsulfonyl)amino]pyrazin-2- yl}methyl)amino]-5- (trifluoromethyl)pyrimidin-2- yl}amino)benzamide (317)::US10450297, Example 317::US10450297, Example 318

SMILES: CNC(=O)c1ccc(cc1)Nc2ncc(c(n2)NCc3c(nccn3)N(C)S(=O)(=O)C)C(F)(F)F

InChI Key: InChIKey=FWLMVFUGMHIOAA-UHFFFAOYSA-N

Data: 19 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 418817   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1 [410-689] (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.79	n/a	n/a	n/a	n/a	n/a	n/a
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Protein-tyrosine kinase 2-beta (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a
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Focal adhesion kinase 1 (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
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Focal adhesion kinase 1 (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Focal adhesion kinase 1 (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.630	n/a	n/a	n/a	n/a	n/a	n/a
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Focal adhesion kinase 1 (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<0.5	n/a	n/a	n/a	n/a	n/a	n/a
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Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	129	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK3 (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	115	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK2 (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
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NT-3 growth factor receptor (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
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BDNF/NT-3 growth factors receptor (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
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High affinity nerve growth factor receptor (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein-tyrosine kinase 2-beta (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	87	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	273	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Focal adhesion kinase 1 (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Focal adhesion kinase 1 (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Focal adhesion kinase 1 (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Focal adhesion kinase 1 (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Focal adhesion kinase 1 (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Focal adhesion kinase 1 [410-689] (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<0.595	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Focal adhesion kinase 1 (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein-tyrosine kinase 2-beta (Human)	BDBM418817 (US10450297, Example 317 | US10450297, Example 318 ...) Show SMILES Show InChI	GoogleScholar	UniChem		6.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair