BDBM420962 US10479798, Compound 21

SMILES COc1cc2c(ccc3c2C[C@@H]([C@H](O3)c4cc(c(cc4F)F)F)N)cc1C#N

InChI Key InChIKey=OGGAKUIGELBYAA-UHFFFAOYSA-N

Data  2 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 420962   

TargetDipeptidyl peptidase 4(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 420962BDBM420962(US10479798, Compound 21)
Affinity DataKd:  0.177nMAssay Description:Binding affinity to DPP4 (unknown origin) expressed in baculovirus expressing systemMore data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 4(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 420962BDBM420962(US10479798, Compound 21)
Affinity DataIC50: 2nMAssay Description:Screening Method:Name of method: Activity Evaluation of DPP4, Fluorescence.Instrument: Microplate reader, Envision (PerkinElmer, USA).Material: human...More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 420962BDBM420962(US10479798, Compound 21)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed