BDBM424361 US10508120, Compound I-816::US10508120, Compound I-908::US10577373, Compound I-908::US11046698, Compound I-816::US11414431, Compound I-264

SMILES: CNc1cc(nc2n1ncc2C(=O)N[C@@H]3CC[C@H]3OC)NC4=CC=CN(C4=O)c5ccccn5

InChI Key: InChIKey=BWINBHTTZLVXGT-UHFFFAOYSA-N

Data: 1 IC50  12 Kd

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 424361   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Human)	BDBM424361 (US10508120, Compound I-816 | US10508120, Compound ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	<0.200	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Human)	BDBM424361 (US10508120, Compound I-816 | US10508120, Compound ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	<0.200	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Human)	BDBM424361 (US10508120, Compound I-816 | US10508120, Compound ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	<0.200	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Human)	BDBM424361 (US10508120, Compound I-816 | US10508120, Compound ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	<0.200	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Human)	BDBM424361 (US10508120, Compound I-816 | US10508120, Compound ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	<0.200	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Human)	BDBM424361 (US10508120, Compound I-816 | US10508120, Compound ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	<0.200	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Human)	BDBM424361 (US10508120, Compound I-816 | US10508120, Compound ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	<0.200	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM424361 (US10508120, Compound I-816 | US10508120, Compound ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.00300	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM424361 (US10508120, Compound I-816 | US10508120, Compound ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM424361 (US10508120, Compound I-816 | US10508120, Compound ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.00400	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM424361 (US10508120, Compound I-816 | US10508120, Compound ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	<200	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM424361 (US10508120, Compound I-816 | US10508120, Compound ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM424361 (US10508120, Compound I-816 | US10508120, Compound ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair