BDBM4287 (5-Hydroxy-2-oxo-3-indolinidene)malononitrile::2-(5-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-ylidene)propanedinitrile::Tyrphostin deriv. 18

SMILES [#8]-c1ccc2-[#7]-[#6](=O)\[#6](=[#6](\C#N)C#N)-c2c1

InChI Key InChIKey=DVGOOYYUJBNLCS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 4287   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM4287((5-Hydroxy-2-oxo-3-indolinidene)malononitrile | 2-...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of EGFR in human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM4287((5-Hydroxy-2-oxo-3-indolinidene)malononitrile | 2-...)
Affinity DataIC50:  1.25E+4nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed