BDBM430029 US10538528, Compound 5

SMILES CC(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1cnc(F)c(F)c1

InChI Key InChIKey=RJHWXUSDSADOOD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 430029   

TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430029(US10538528, Compound 5)
Affinity DataIC50:  3.5nMAssay Description:Akt1 was prepared and assays of inhibitory activity of the compound according to the present invention against Akt1 kinase activity in vitro were con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430029(US10538528, Compound 5)
Affinity DataIC50:  0.300nMAssay Description:S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430029(US10538528, Compound 5)
Affinity DataIC50:  0.700nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent