BDBM4301 (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide::CHEMBL296407::Tyrphostin deriv. 40::benzylidenemalononitrile (BMN) deriv. 46

SMILES: c1cc(c(cc1/C=C(\C#N)/C(=O)N)O)O

InChI Key: InChIKey=USOXQZNJFMKTKJ-UHFFFAOYSA-N

Data: 1 KI  13 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 4301   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Human)	BDBM4301 ((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Integrase (Human immunodeficiency virus type 1)	BDBM4301 ((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM4301 ((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM4301 ((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Dynamin-1 (Human)	BDBM4301 ((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM4301 ((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM4301 ((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM4301 ((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM4301 ((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosyl-DNA phosphodiesterase 1 (Human)	BDBM4301 ((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM4301 ((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.47E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM4301 ((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM4301 ((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...) Show SMILES Show InChI	GoogleScholar	UniChem		3.50E+3	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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