BDBM4302 (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1R)-1-phenylethyl]prop-2-enamide::Tyrphostin deriv. 44::cid_5328772

SMILES C[C@@H](NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N)c1ccccc1

InChI Key InChIKey=UMGQVUWXNOJOSJ-KMHUVPDISA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4302   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4302((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1R)-1-phe...)
Affinity DataIC50:  400nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4302((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1R)-1-phe...)
Affinity DataIC50:  2.51E+3nMAssay Description:Inhibitory activity against epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Tennessee Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM4302((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1R)-1-phe...)
Affinity DataIC50:  3.72E+4nMAssay Description:Inhibitory activity tested against protein kinase HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge T antigen(Simian virus 40)
Southern Research Specialized Biocontainment Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM4302((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1R)-1-phe...)
Affinity DataEC50: >5.00E+4nMAssay Description:Southern Research's Specialized Biocontainment Screening Center (SRSBSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Librarie...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay