BDBM4309 Tyrphostin deriv. 58::ethyl 2-[(2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamido]-3-phenylpropanoate

SMILES CCOC(=O)C(Cc1ccccc1)NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N

InChI Key InChIKey=IZNDRNBAQQZJSB-MHWRWJLKSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4309   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4309(Tyrphostin deriv. 58 | ethyl 2-[(2E)-2-cyano-3-(3,...)
Affinity DataIC50:  1.53E+3nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4309(Tyrphostin deriv. 58 | ethyl 2-[(2E)-2-cyano-3-(3,...)
Affinity DataIC50:  4.90E+4nMAssay Description:Inhibitory activity against epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Tennessee Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM4309(Tyrphostin deriv. 58 | ethyl 2-[(2E)-2-cyano-3-(3,...)
Affinity DataIC50:  3.31E+5nMAssay Description:Inhibitory activity tested against protein kinase HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed