BDBM431433 US10550105, Example 378::US10870641, Example 378::US11014913, Example 378

SMILES FC(F)(F)c1cnc(nc1)N1CCN(CC1)C(=O)c1cncc(OCC2N(Cc3ccccc23)c2cn[nH]c(=O)c2C(F)(F)F)c1

InChI Key InChIKey=IHSRDOGNMCNZKB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 431433   

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Ribon Therapeutics

US Patent
LigandPNGBDBM431433(US10550105, Example 378 | US10870641, Example 378 ...)
Affinity DataIC50: 100nMAssay Description:Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Ribon Therapeutics

US Patent
LigandPNGBDBM431433(US10550105, Example 378 | US10870641, Example 378 ...)
Affinity DataIC50: 100nMAssay Description:Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Ribon Therapeutics

US Patent
LigandPNGBDBM431433(US10550105, Example 378 | US10870641, Example 378 ...)
Affinity DataIC50: 100nMAssay Description:Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent