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BDBM4327 (2E)-3-[4-(2,2-dicyanoeth-1-en-1-yl)phenyl]prop-2-enoic acid::benzylidenemalononitrile (BMN) deriv. 11

SMILES: [#8]-[#6](=O)\[#6]=[#6]\c1ccc(\[#6]=[#6](/C#N)C#N)cc1

InChI Key: InChIKey=FYUKHNUSVGJQFX-AATRIKPKSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 4327   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4327
PNG
((2E)-3-[4-(2,2-dicyanoeth-1-en-1-yl)phenyl]prop-2-...)
Show SMILES OC(=O)\C=C\c1ccc(C=C(C#N)C#N)cc1
Show InChI InChI=1S/C13H8N2O2/c14-8-12(9-15)7-11-3-1-10(2-4-11)5-6-13(16)17/h1-7H,(H,16,17)/b6-5+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.50E+5 -5.16 4.50E+5n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 32: 2344-52 (1989)


Article DOI: 10.1021/jm060967z
BindingDB Entry DOI: 10.7270/Q2G44NHF
More data for this
Ligand-Target Pair