BDBM432968 N-((2R,4R)-1-(4-(2- aminoethoxy)benzoyl)-2-methylpiperidin- 4-yl)-5-cyclopropylisoxazole-3- carboxamide::US10577363, Compound 671

SMILES C[C@@H]1C[C@@H](CCN1C(=O)c1ccc(OCCN)cc1)NC(=O)c1cc(on1)C1CC1

InChI Key InChIKey=UUGUKWGCFDYJQG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 432968   

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandPNGBDBM432968(US10577363, Compound 671 | N-((2R,4R)-1-(4-(2- ami...)
Affinity DataIC50: 104nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent