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BDBM4342 (2E)-2-cyano-3-phenylprop-2-enoic acid::benzylidenemalononitrile (BMN) deriv. 26

SMILES: OC(=O)C(=C\c1ccccc1)\C#N

InChI Key: InChIKey=CDUQMGQIHYISOP-RMKNXTFCSA-N

Data: 1 KI  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 4342   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4342
PNG
((2E)-2-cyano-3-phenylprop-2-enoic acid | benzylide...)
Show SMILES OC(=O)C(=C\c1ccccc1)\C#N
Show InChI InChI=1S/C10H7NO2/c11-7-9(10(12)13)6-8-4-2-1-3-5-8/h1-6H,(H,12,13)/b9-6+
PDB
MMDB

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Similars

Article
PubMed
8.50E+5n/a>2.50E+6n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 32: 2344-52 (1989)


Article DOI: 10.1021/jm00130a020
BindingDB Entry DOI: 10.7270/Q2G44NHF
More data for this
Ligand-Target Pair