BDBM445704 LX1606::US10683309, Example LX1606

SMILES CCOC(=O)[C@@H](N)Cc1ccc(cc1)-c1cc(O[C@H](c2ccc(Cl)cc2-n2ccc(C)n2)C(F)(F)F)nc(N)n1

InChI Key InChIKey=MDSQOJYHHZBZKA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 445704   

TargetTryptophan 5-hydroxylase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM445704(LX1606 | US10683309, Example LX1606)
Affinity DataIC50: 700nMAssay Description:Inhibition of human TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Max-DelbrÜCk-Centrum FÜR Molekulare Medizin

US Patent
LigandPNGBDBM445704(LX1606 | US10683309, Example LX1606)
Affinity DataIC50: 730nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM445704(LX1606 | US10683309, Example LX1606)
Affinity DataIC50: 770nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
US Patent