BDBM455058 US10730874, Compound I-82::US11352356, Compound I-82

SMILES COC(=O)CCc1c(cnn1Cc1cn2cc(ccc2n1)C1CC1)C(=O)NCc1ncn2ccc(Cl)cc12

InChI Key InChIKey=IMPPNGAYPDFVGK-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 455058   

TargetPlasma kallikrein(Human)
Shire Human Genetic Therapies

US Patent
LigandPNGBDBM455058(US10730874, Compound I-82 | US11352356, Compound I...)
Affinity DataEC50:  55nMAssay Description:Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Shire Human Genetic Therapies

US Patent
LigandPNGBDBM455058(US10730874, Compound I-82 | US11352356, Compound I...)
Affinity DataEC50:  55nMAssay Description:Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
US Patent