BDBM4552 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile::4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile::BOSUTINIB::CHEMBL288441::SKI-606

SMILES: CN1CCN(CC1)CCCOc2cc3c(cc2OC)c(c(cn3)C#N)Nc4cc(c(cc4Cl)Cl)OC

InChI Key: InChIKey=UBPYILGKFZZVDX-UHFFFAOYSA-N

Data: 5 KI  105 IC50  457 Kd

PDB links: 14 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 582 hits for monomerid = 4552   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.80	n/a	n/a	n/a	n/a	7.5	37
TBA									Citation and Details
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Tyrosine-protein kinase ABL1 (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.80	n/a	n/a	n/a	n/a	7.5	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.60	n/a	n/a	n/a	n/a	7.5	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.80	n/a	n/a	n/a	n/a	7.5	37
TBA									Citation and Details
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Serine/threonine-protein kinase TBK1 (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Ephrin type-A receptor 2 [596-900] (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ephrin type-A receptor 2 [596-900] (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS (Mouse)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase 2 (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	106	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	133	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	704	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1/ABL2 (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	133	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	704	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase receptor UFO (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Cyclin-G-associated kinase (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Epidermal growth factor receptor (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-G-associated kinase (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mitogen-activated protein kinase kinase kinase kinase 3 (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase Fyn (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Broad substrate specificity ATP-binding cassette transporter ABCG2 (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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ALK tyrosine kinase receptor/Nucleophosmin (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Activated CDC42 kinase 1 (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Protein delta homolog 1 (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	670	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase SIK1 (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase SIK2 (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase SIK3 (Human)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM4552 (CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair