BDBM4567 4-anilinoquinazoline deriv. 2::BMC163482 Compound 1::CHEMBL285063::N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}prop-2-enamide::US9422297, PD168393

SMILES: C=CC(=O)Nc1ccc2c(c1)c(ncn2)Nc3cccc(c3)Br

InChI Key: InChIKey=HTUBKQUPEREOGA-UHFFFAOYSA-N

Data: 40 IC50

PDB links: 4 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 40 hits for monomerid = 4567   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Blk (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.47E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase STK11 (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytoplasmic tyrosine-protein kinase BMX (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase BTK (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.83E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ITK/TSK (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK3 (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Blk (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytoplasmic tyrosine-protein kinase BMX (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	303	n/a	n/a	n/a	n/a	n/a	n/a
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Cytoplasmic tyrosine-protein kinase BMX (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	324	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK3 (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.69	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	152	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fyn (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Chicken)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	114	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.4	25
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					More data for this Ligand-Target Pair
Epidermal growth factor receptor [668-1210] (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0800	n/a	n/a	n/a	n/a	7.5	23
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Epidermal growth factor receptor [696-1210,T790M] (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.5	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src [251-533,S345C] (Chicken)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	340	n/a	n/a	n/a	n/a	7.5	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src [251-533,T338M,S345C] (Chicken)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.81E+3	n/a	n/a	n/a	n/a	7.5	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	521	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-4 (Human)	BDBM4567 (CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair