BindingDB PrimarySearch

BDBM46355 DIGOXIN::MLS000069819::SMR000059217::US10668094, Compound Digoxin::US12343350, Compound DIGOXIN::cid_2724385

SMILES: C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5C[C@H]([C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)O)C)C)C)O)O

InChI Key: InChIKey=LTMHDMANZUZIPE-UHFFFAOYSA-N

Data: 8 KI 28 IC50 1 Kd

PDB links: 4 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 37 hits for monomerid = 46355
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
ATP-dependent translocase ABCB1 (Mouse)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Signal transducer and activator of transcription 3 [702-738,740-752] (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.86E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Nuclear receptor ROR-gamma (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium/potassium-transporting ATPase subunit alpha-1 (Dog)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium/potassium-transporting ATPase subunit alpha-1 (Dog)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-dependent translocase ABCB1 (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-dependent translocase ABCB1 (Mouse)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-dependent translocase ABCB1 (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Nuclear receptor ROR-gamma (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
ATP-dependent translocase ABCB1 (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier organic anion transporter family member 1B3 (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier organic anion transporter family member 1B1 (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Nuclear receptor ROR-gamma (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	109	n/a	n/a	n/a	n/a	n/a
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Nuclear receptor ROR-gamma (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Nuclear receptor ROR-gamma (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.98E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium/potassium-transporting ATPase subunit alpha-1 (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Nuclear receptor ROR-gamma (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Signal transducer and activator of transcription 1-alpha/beta (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>5.57E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Replicase polyprotein 1ab (2019-nCoV)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium/potassium-transporting ATPase subunit alpha-1 (Dog)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
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Bile salt export pump (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.64E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium/potassium-transporting ATPase subunit alpha-4/beta-1 (Rat)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
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Nuclear receptor ROR-gamma (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	8.54E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Nuclear receptor ROR-gamma (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.36E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Nuclear receptor ROR-gamma (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7.01E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Solute carrier organic anion transporter family member 1A4 (Rat)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	37	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium/potassium-transporting ATPase subunit alpha-2/beta-3 (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	42.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Sodium/potassium-transporting ATPase subunit alpha-2/beta-1 (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	55	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium/potassium-transporting ATPase subunit alpha-2/beta-2 (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	58	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Sodium/potassium-transporting ATPase subunit alpha-2/beta-1 (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	58.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Sodium/potassium-transporting ATPase subunit alpha-1/beta-1 (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	189	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Sodium/potassium-transporting ATPase subunit alpha-1/beta-1 (Human)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	268	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Solute carrier organic anion transporter family member 1A4 (Rat)	BDBM46355 (MLS000069819 \| cid_2724385 \| SMR000059217 \| DIGOXI...) Show SMILES Show InChI	GoogleScholar	UniChem	580	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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