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BDBM47274 US9018217, 4-(2-(2-((8-chloro-[1,2,4]triazolo[1,5-a]pyridin-2-yl)methylthio)-4-phenyl-1H-imidazol-1-ypethyl)morpholine::US9592230, 4-(2-(2-((8-chloro-[1,2,4]triazolo[1,5-a]pyridin-2-yl)methylthio)-4-phenyl-1H-imidazol-1-yl)ethyl)morpholine

SMILES: Clc1cccn2nc(CSc3nc(cn3CCN3CCOCC3)-c3ccccc3)nc12

InChI Key: InChIKey=ZZHFSNQWJOWXMV-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 47274   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47274
PNG
(US9018217, 4-(2-(2-((8-chloro-[1,2,4]triazolo[1,5-...)
Show SMILES Clc1cccn2nc(CSc3nc(cn3CCN3CCOCC3)-c3ccccc3)nc12
Show InChI InChI=1S/C22H23ClN6OS/c23-18-7-4-8-29-21(18)25-20(26-29)16-31-22-24-19(17-5-2-1-3-6-17)15-28(22)10-9-27-11-13-30-14-12-27/h1-8,15H,9-14,16H2
PDB
MMDB

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UniProtKB/TrEMBL

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PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 17n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q2CV4KSH
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47274
PNG
(US9018217, 4-(2-(2-((8-chloro-[1,2,4]triazolo[1,5-...)
Show SMILES Clc1cccn2nc(CSc3nc(cn3CCN3CCOCC3)-c3ccccc3)nc12
Show InChI InChI=1S/C22H23ClN6OS/c23-18-7-4-8-29-21(18)25-20(26-29)16-31-22-24-19(17-5-2-1-3-6-17)15-28(22)10-9-27-11-13-30-14-12-27/h1-8,15H,9-14,16H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 17n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9018217 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DS1
More data for this
Ligand-Target Pair