BDBM47353 BDBM143220::US9029362, 173::US9687494, 25

SMILES: CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F

InChI Key: InChIKey=YHYKUSGACIYRML-UHFFFAOYSA-N

Data: 10 KI  8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 47353   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 2 (Human)	BDBM47353 (US9687494, 25 | BDBM143220 | US9029362, 173) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-secretase 1 (Human)	BDBM47353 (US9687494, 25 | BDBM143220 | US9029362, 173) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-secretase 1 (Human)	BDBM47353 (US9687494, 25 | BDBM143220 | US9029362, 173) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	85	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-secretase 1 (Human)	BDBM47353 (US9687494, 25 | BDBM143220 | US9029362, 173) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-secretase 1 (Human)	BDBM47353 (US9687494, 25 | BDBM143220 | US9029362, 173) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
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Cathepsin D (Human)	BDBM47353 (US9687494, 25 | BDBM143220 | US9029362, 173) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-secretase 1 (Human)	BDBM47353 (US9687494, 25 | BDBM143220 | US9029362, 173) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-secretase 2 (Human)	BDBM47353 (US9687494, 25 | BDBM143220 | US9029362, 173) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.380	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-secretase 2 (Human)	BDBM47353 (US9687494, 25 | BDBM143220 | US9029362, 173) Show SMILES Show InChI	GoogleScholar	UniChem		0.370	-13.1	n/a	n/a	n/a	n/a	n/a	5.0	30
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					More data for this Ligand-Target Pair
Beta-secretase 2 (Human)	BDBM47353 (US9687494, 25 | BDBM143220 | US9029362, 173) Show SMILES Show InChI	GoogleScholar	UniChem		0.370	-13.1	n/a	n/a	n/a	n/a	n/a	5.0	30
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Beta-secretase 2 (Human)	BDBM47353 (US9687494, 25 | BDBM143220 | US9029362, 173) Show SMILES Show InChI	GoogleScholar	UniChem		0.470	-12.9	n/a	n/a	n/a	n/a	n/a	5.0	30
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Beta-secretase 2 (Human)	BDBM47353 (US9687494, 25 | BDBM143220 | US9029362, 173) Show SMILES Show InChI	GoogleScholar	UniChem		0.470	-12.9	n/a	n/a	n/a	n/a	n/a	5.0	30
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Beta-secretase 1 (Human)	BDBM47353 (US9687494, 25 | BDBM143220 | US9029362, 173) Show SMILES Show InChI	GoogleScholar	UniChem		1.75	-12.1	n/a	n/a	n/a	n/a	n/a	5.0	30
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					More data for this Ligand-Target Pair
Beta-secretase 1 (Human)	BDBM47353 (US9687494, 25 | BDBM143220 | US9029362, 173) Show SMILES Show InChI	GoogleScholar	UniChem		1.75	n/a	n/a	n/a	n/a	n/a	n/a	5.01	n/a
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Beta-secretase 1 (Human)	BDBM47353 (US9687494, 25 | BDBM143220 | US9029362, 173) Show SMILES Show InChI	GoogleScholar	UniChem		4.88	-11.5	n/a	n/a	n/a	n/a	n/a	5.0	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-secretase 1 (Human)	BDBM47353 (US9687494, 25 | BDBM143220 | US9029362, 173) Show SMILES Show InChI	GoogleScholar	UniChem		4.88	-11.5	n/a	n/a	n/a	n/a	n/a	5.0	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-secretase 2 (Human)	BDBM47353 (US9687494, 25 | BDBM143220 | US9029362, 173) Show SMILES Show InChI	GoogleScholar	UniChem		370	n/a	n/a	n/a	n/a	n/a	n/a	5.0	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-secretase 1 (Human)	BDBM47353 (US9687494, 25 | BDBM143220 | US9029362, 173) Show SMILES Show InChI	GoogleScholar	UniChem		1.75E+3	n/a	n/a	n/a	n/a	n/a	n/a	5.0	n/a
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					More data for this Ligand-Target Pair