BDBM479096 (R)-1-(6-(3-((5-chloropyrimidin-2- yl)amino)pyrrolidine-1- carbonyl)indolin-1-yl)prop-2-en-1- one::US10894788, Example 136::US11390618, Example 136

SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc3CCN(C(=O)C=C)c3c2)nc1

InChI Key InChIKey=URJZAWIKZMCHJX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 479096   

TargetCyclin-dependent kinase 12(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM479096((R)-1-(6-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Affinity DataIC50: 550nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM479096((R)-1-(6-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Affinity DataIC50: 550nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent