BDBM480256 US10899738, Cpd. No 317::rac-(1R,2S)-2-(4-(1-((1-(4- (cyclopropylsulfonyl)phenyl) azetidin-3- yl)methyl)piperidin-4-yl)-6- fluoro-2-methyl-1,2,3,4- tetrahydroisoquinolin-4- yl)cyclopentyl acetate

SMILES CN1Cc2ccc(F)cc2C(C1)([C@@H]1CCC[C@H]1OC(C)=O)C1CCN(CC2CN(C2)c2ccc(cc2)S(=O)(=O)C2CC2)CC1

InChI Key InChIKey=CMKBAOQEJWGPEB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 480256   

TargetMenin(Human)
University of Michigan

US Patent
LigandPNGBDBM480256(rac-(1R,2S)-2-(4-(1-((1-(4- (cyclopropylsulfonyl)p...)
Affinity DataIC50: 161nMAssay Description:A fluorescence polarization (FP) competitive binding assay was used to determine the binding affinities of representative menin inhibitors. A FAM lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent