BDBM4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US20240058459, Compound Sunit-inib::US20250161319, Example Sunitinib::US9163010, Sunitinib::US9914707, SU11248

SMILES: CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C

InChI Key: InChIKey=WINHZLLDWRZWRT-UHFFFAOYSA-N

Data: 39 KI  258 IC50  1458 Kd  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1756 hits for monomerid = 4814   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	80	n/a	n/a	n/a	n/a	7.5	22
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Fibroblast growth factor receptor 1 (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	7.5	22
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Platelet-derived growth factor receptor beta (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 [201-500] (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 [201-500,Q252H] (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 [201-500,Y253F] (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 [201-500,E255K] (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 [201-500,M351T] (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 [201-500,F359V] (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 [201-500,H396P] (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 [201-500,T315I] (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 [201-500,T315N] (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a
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Mast/stem cell growth factor receptor Kit [N822K] (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a
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Mast/stem cell growth factor receptor Kit [V559D] (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mast/stem cell growth factor receptor Kit [V559D,T670I] (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase ABL1 [T315I] (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	140	n/a	n/a	n/a	7.4	25
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ALK tyrosine kinase receptor (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	170	n/a	n/a	n/a	7.4	25
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Aurora kinase A (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	7.4	25
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Aurora kinase B (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a
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Aurora kinase C (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	220	n/a	n/a	n/a	7.4	25
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Tyrosine-protein kinase receptor UFO (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a
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Bone morphogenetic protein receptor type-2 (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	570	n/a	n/a	n/a	7.4	25
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Cyclin-dependent kinase 7 (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	330	n/a	n/a	n/a	7.4	23
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Dual specificity protein kinase CLK1 [R432A] (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	22	n/a	n/a	n/a	7.4	23
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Dual specificity protein kinase CLK4 (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	29	n/a	n/a	n/a	7.4	23
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Macrophage colony-stimulating factor 1 receptor (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Epithelial discoidin domain-containing receptor 1 (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Epidermal growth factor receptor [G719C] (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.80E+3	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 3 [1-975] (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.10E+3	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 7 (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	960	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ephrin type-A receptor 7 (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.40E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.80	n/a	n/a	n/a	7.4	25
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					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.470	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [D835H] (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.30	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.30	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.990	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [N841I] (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.40	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Vascular endothelial growth factor receptor 3 (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	50	n/a	n/a	n/a	7.4	25
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Tyrosine-protein kinase FRK (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	530	n/a	n/a	n/a	7.4	25
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P2Y purinoceptor 14 (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	430	n/a	n/a	n/a	7.4	25
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Mitogen-activated protein kinase kinase kinase kinase 1 (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mitogen-activated protein kinase kinase kinase kinase 3 (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase kinase 5 (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Mer (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase 4 (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase 3 (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a
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Muscle, skeletal receptor tyrosine-protein kinase (Human)	BDBM4814 (SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a
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