BDBM4818 5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-N-[2-(pyrrolidin-1-yl)ethyl]-1H-pyrrole-3-carboxamide::SU11248 analog 12f

SMILES: Cc1c([nH]c(c1C(=O)NCCN2CCCC2)C)/C=C\3/c4cc(ccc4NC3=O)F

InChI Key: InChIKey=SRSGVKWWVXWSJT-UHFFFAOYSA-N

Data: 4 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 4818   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Human)	BDBM4818 (5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-yli...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	60	n/a	n/a	n/a	n/a	7.5	22
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Fibroblast growth factor receptor 1 (Human)	BDBM4818 (5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-yli...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor beta (Human)	BDBM4818 (5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-yli...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM4818 (5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-yli...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase tousled-like 2 (Human)	BDBM4818 (5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-yli...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
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