BDBM482158 BDBM50242742::TAE684

SMILES: CC(C)S(=O)(=O)c1ccccc1Nc2c(cnc(n2)Nc3ccc(cc3OC)N4CCC(CC4)N5CCN(CC5)C)Cl

InChI Key: InChIKey=QQWUGDVOUVUTOY-UHFFFAOYSA-N

Data: 58 IC50  450 Kd  21 EC50

PDB links: 3 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 530 hits for monomerid = 482158   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase/endoribonuclease IRE1 [547-977] (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	65	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
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ALK tyrosine kinase receptor (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [1326-2527] (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [1326-2527,G2019S] (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [1326-2527,A2016T] (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	93.3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [1326-2527,A2016T,G2019S] (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	21.9	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase receptor TYRO3 (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	7.20E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Mer (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	536	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fes/Fps (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	569	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	218	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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ALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4 (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4 (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
NUAK family SNF1-like kinase 1 (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NUAK family SNF1-like kinase 2 (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a
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Protein delta homolog 1 (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase DCLK1 (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Macrophage-stimulating protein receptor (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Cytoplasmic tyrosine-protein kinase BMX (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.58E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Mouse)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Lysine--tRNA ligase (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.47E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.22E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Insulin receptor (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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Ephrin type-B receptor 4 (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor beta (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	554	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	872	n/a	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 1 (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.67E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ZAP-70 (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Cytoplasmic tyrosine-protein kinase BMX (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Lysine--tRNA ligase (Human)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.86E+5	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Insulin receptor (Rat)	BDBM482158 (TAE684 | BDBM50242742) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair