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BDBM48554 (4Z)-3-hydroxy-4-(4-quinolin-8-yl-1,2-dihydropyrazol-3-ylidene)cyclohexa-2,5-dien-1-one::(4Z)-3-hydroxy-4-[4-(8-quinolinyl)-1,2-dihydropyrazol-3-ylidene]-1-cyclohexa-2,5-dienone::(4Z)-3-hydroxy-4-[4-(8-quinolyl)-3-pyrazolin-3-ylidene]cyclohexa-2,5-dien-1-one::(4Z)-3-oxidanyl-4-(4-quinolin-8-yl-1,2-dihydropyrazol-3-ylidene)cyclohexa-2,5-dien-1-one::MLS000054375::SMR000065872::cid_5668702

SMILES: Oc1ccc(-c2n[nH]cc2-c2cccc3cccnc23)c(O)c1

InChI Key: InChIKey=RNARQCIJGRDWAK-UHFFFAOYSA-N

Data: 2 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 48554   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
eukaryotic translation initiation factor 4 gamma, 1 isoform 4


(Homo sapiens)
BDBM48554
PNG
((4Z)-3-hydroxy-4-(4-quinolin-8-yl-1,2-dihydropyraz...)
Show SMILES Oc1ccc(-c2n[nH]cc2-c2cccc3cccnc23)c(O)c1
Show InChI InChI=1S/C18H13N3O2/c22-12-6-7-14(16(23)9-12)18-15(10-20-21-18)13-5-1-3-11-4-2-8-19-17(11)13/h1-10,22-23H,(H,20,21)
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
n/an/a 6.40E+4n/an/an/an/an/an/a



Emory University Molecular Libraries Screening Center

Curated by PubChem BioAssay


Assay Description
Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation NIH Molecular Libraries Screening Centers Network [MLSC...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2RN3686
More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens)
BDBM48554
PNG
((4Z)-3-hydroxy-4-(4-quinolin-8-yl-1,2-dihydropyraz...)
Show SMILES Oc1ccc(-c2n[nH]cc2-c2cccc3cccnc23)c(O)c1
Show InChI InChI=1S/C18H13N3O2/c22-12-6-7-14(16(23)9-12)18-15(10-20-21-18)13-5-1-3-11-4-2-8-19-17(11)13/h1-10,22-23H,(H,20,21)
PDB
MMDB

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B.MOAD
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PC cid
PC sid
UniChem
n/an/an/an/a>5.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q280513R
More data for this
Ligand-Target Pair
large T antigen


(Simian virus 40)
BDBM48554
PNG
((4Z)-3-hydroxy-4-(4-quinolin-8-yl-1,2-dihydropyraz...)
Show SMILES Oc1ccc(-c2n[nH]cc2-c2cccc3cccnc23)c(O)c1
Show InChI InChI=1S/C18H13N3O2/c22-12-6-7-14(16(23)9-12)18-15(10-20-21-18)13-5-1-3-11-4-2-8-19-17(11)13/h1-10,22-23H,(H,20,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/an/an/a 1.73E+4n/an/an/an/a



Southern Research Specialized Biocontainment Screening Center

Curated by PubChem BioAssay


Assay Description
Southern Research's Specialized Biocontainment Screening Center (SRSBSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Librarie...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2ZK5F47
More data for this
Ligand-Target Pair
large T antigen


(Simian virus 40)
BDBM48554
PNG
((4Z)-3-hydroxy-4-(4-quinolin-8-yl-1,2-dihydropyraz...)
Show SMILES Oc1ccc(-c2n[nH]cc2-c2cccc3cccnc23)c(O)c1
Show InChI InChI=1S/C18H13N3O2/c22-12-6-7-14(16(23)9-12)18-15(10-20-21-18)13-5-1-3-11-4-2-8-19-17(11)13/h1-10,22-23H,(H,20,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 2.57E+4n/an/an/an/an/an/a



Southern Research Specialized Biocontainment Screening Center

Curated by PubChem BioAssay


Assay Description
A biochemical assay using the ADP-Hunter methodology, purified TAg, and ATP to identify compounds that inhibit the ATPase activity of Tag Southern Re...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2M61HQ8
More data for this
Ligand-Target Pair