BDBM488779 (R)-N-(3-(5-fluoro-2- (2-fluoro-3- (methylsulfonyl)phenyl amino)pyrimidin-4-yl)- 1H-indol-7-yl)-3- methoxy-2-(4- methylpiperazin-1- yl)propanamide::US10961228, Example 35

SMILES: COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F

InChI Key: InChIKey=JNUZADQZHYFJGW-UHFFFAOYSA-N

Data: 10 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 488779   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 [866-1154] (Human)	BDBM488779 (US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [831-1132] (Human)	BDBM488779 (US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124] (Human)	BDBM488779 (US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM488779 (US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM488779 (US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM488779 (US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM488779 (US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM488779 (US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	686	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM488779 (US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM488779 (US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	657	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair