BDBM4901 3-(5-{[(3Z)-6-(3-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrol-3-yl)propanoic acid::3-substituted indolin-2-one 16g::CHEMBL358728

SMILES COc1cccc(c1)-c1ccc2\C(=C\c3[nH]c(C)c(CCC(O)=O)c3C)C(=O)Nc2c1

InChI Key InChIKey=XLHWOGDAUMWGHR-BKUYFWCQSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 4901   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Sugen

LigandPNGBDBM4901(3-(5-{[(3Z)-6-(3-methoxyphenyl)-2-oxo-2,3-dihydro-...)
Affinity DataIC50:  300nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Sugen

LigandPNGBDBM4901(3-(5-{[(3Z)-6-(3-methoxyphenyl)-2-oxo-2,3-dihydro-...)
Affinity DataIC50:  1.40E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Sugen

LigandPNGBDBM4901(3-(5-{[(3Z)-6-(3-methoxyphenyl)-2-oxo-2,3-dihydro-...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human FGFR1 kinase expressed in insect cell by HTRF detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sugen

LigandPNGBDBM4901(3-(5-{[(3Z)-6-(3-methoxyphenyl)-2-oxo-2,3-dihydro-...)
Affinity DataIC50: >1.00E+5nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Sugen

LigandPNGBDBM4901(3-(5-{[(3Z)-6-(3-methoxyphenyl)-2-oxo-2,3-dihydro-...)
Affinity DataIC50:  1.79E+4nMAssay Description:Inhibition of rhFGF2-induced cellular proliferation of HUVECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Sugen

LigandPNGBDBM4901(3-(5-{[(3Z)-6-(3-methoxyphenyl)-2-oxo-2,3-dihydro-...)
Affinity DataIC50:  100nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed