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BDBM50000901 4-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyric acid methyl ester::CHEMBL91634

SMILES: COC(=O)CCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1

InChI Key: InChIKey=MNUCPNWZRLQCDI-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50000901   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000901
PNG
(4-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES COC(=O)CCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-19-13-9-10-8-11(23-7-3-4-14(20)22-2)5-6-12(10)17-15(13)18-16(19)21/h5-6,8-9H,3-4,7H2,1-2H3,(H,17,18,21)
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Article
PubMed
n/an/an/an/a 1.90E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50000901
PNG
(4-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES COC(=O)CCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-19-13-9-10-8-11(23-7-3-4-14(20)22-2)5-6-12(10)17-15(13)18-16(19)21/h5-6,8-9H,3-4,7H2,1-2H3,(H,17,18,21)
PDB
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PC cid
PC sid
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Article
PubMed
n/an/a 7.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000901
PNG
(4-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES COC(=O)CCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-19-13-9-10-8-11(23-7-3-4-14(20)22-2)5-6-12(10)17-15(13)18-16(19)21/h5-6,8-9H,3-4,7H2,1-2H3,(H,17,18,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

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GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


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Article
PubMed
n/an/a 1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


J Med Chem 35: 2672-87 (1992)


Article DOI: 10.1021/jm00092a019
BindingDB Entry DOI: 10.7270/Q2513X52
More data for this
Ligand-Target Pair