BDBM50001489 3-Methyl-1-propyl-3,7-dihydro-purine-2,6-dione::CHEMBL112369

SMILES CCCn1c(=O)n(C)c2nc[nH]c2c1=O

InChI Key InChIKey=UEGOAAXVUJWIHJ-UHFFFAOYSA-N

Data  4 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50001489   

TargetAdenosine receptor A1(Guinea pig)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001489(CHEMBL112369 | 3-Methyl-1-propyl-3,7-dihydro-purin...)
Affinity DataKi:  3.40E+3nMAssay Description:Affinity against adenosine A1 receptor in the brain membranes by the displacement of [3H]CPX.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Pharmazeutische Chemie

Curated by ChEMBL
LigandPNGBDBM50001489(CHEMBL112369 | 3-Methyl-1-propyl-3,7-dihydro-purin...)
Affinity DataKi:  5.70E+3nMAssay Description:Binding affinity at A1 adenosine receptor in rat brain cortical membrane using [3H]- N6-R-phenylisopropyladenosine (R-PIA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001489(CHEMBL112369 | 3-Methyl-1-propyl-3,7-dihydro-purin...)
Affinity DataEC50:  9.60E+3nMAssay Description:Relaxant activity on the spontaneous tone of isolated guinea pig tracheal ring chains.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001489(CHEMBL112369 | 3-Methyl-1-propyl-3,7-dihydro-purin...)
Affinity DataKi:  2.60E+4nMAssay Description:Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a/A2b(Rat)
Pharmazeutische Chemie

Curated by ChEMBL
LigandPNGBDBM50001489(CHEMBL112369 | 3-Methyl-1-propyl-3,7-dihydro-purin...)
Affinity DataKi:  3.70E+4nMAssay Description:Binding affinity against Adenosine A2 receptor in rat striatal membranes using [3H]5'-(N-ethylcarboxamido)-adenosine (NECA) as the ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed