BDBM50001515 1-Methylxanthine (1-Mx)::3-Methyl-3,7-dihydro-purine-2,6-dione::3-Methyl-3,9-dihydro-purine-2,6-dione(3-methyl xanthine)::CHEMBL619

SMILES CN1c2c([nH]cn2)C(=O)NC1=O

InChI Key InChIKey=GMSNIKWWOQHZGF-UHFFFAOYSA-N

Data  5 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50001515   

TargetAdenosine receptor A1(Rat)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50001515(CHEMBL619 | 3-Methyl-3,7-dihydro-purine-2,6-dione ...)
Affinity DataKi:  3.50E+4nMAssay Description:Inhibition of 1 nM [3H]- N6-(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat cerebral cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a/A2b(Rat)
Pharmazeutische Chemie

Curated by ChEMBL
LigandPNGBDBM50001515(CHEMBL619 | 3-Methyl-3,7-dihydro-purine-2,6-dione ...)
Affinity DataKi:  5.90E+4nMAssay Description:Binding affinity against Adenosine A2 receptor in rat striatal membranes using [3H]5'-(N-ethylcarboxamido)-adenosine (NECA) as the ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001515(CHEMBL619 | 3-Methyl-3,7-dihydro-purine-2,6-dione ...)
Affinity DataEC50: >1.00E+5nMAssay Description:Relaxant activity on the spontaneous tone of isolated guinea pig tracheal ring chains.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a/A2b(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001515(CHEMBL619 | 3-Methyl-3,7-dihydro-purine-2,6-dione ...)
Affinity DataKi:  1.33E+5nMAssay Description:Affinity against adenosine A2 receptor in brain membranes by displacement of [3H]CPXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001515(CHEMBL619 | 3-Methyl-3,7-dihydro-purine-2,6-dione ...)
Affinity DataKi:  1.56E+5nMAssay Description:Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a/A2b(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50001515(CHEMBL619 | 3-Methyl-3,7-dihydro-purine-2,6-dione ...)
Affinity DataKi:  2.40E+5nMAssay Description:Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via adenosine A2 receptor in human platelet membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed