BDBM50001537 CHEMBL3237702::US8841312, 55

SMILES CC1CCC(CC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12

InChI Key InChIKey=RKILQDBEPHSTGP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50001537   

TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50001537(CHEMBL3237702 | US8841312, 55)
Affinity DataIC50:  1.20nMpH: 7.4 T: 2°CAssay Description:The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50001537(CHEMBL3237702 | US8841312, 55)
Affinity DataIC50:  4.40nMpH: 7.4 T: 2°CAssay Description:The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001537(CHEMBL3237702 | US8841312, 55)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001537(CHEMBL3237702 | US8841312, 55)
Affinity DataIC50:  2nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001537(CHEMBL3237702 | US8841312, 55)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin) using histone H1 as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed