BindingDB PrimarySearch

BDBM50001859 (buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione::8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione : (Hydrochloride)::8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione; Hydrochloride(Buspirone)::8-[4-(4-pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione::BUSPAR::BUSPIRONE::CHEMBL49::US10562853, Compound Buspirone

SMILES: c1cnc(nc1)N2CCN(CC2)CCCCN3C(=O)CC4(CCCC4)CC3=O

InChI Key: InChIKey=QWCRAEMEVRGPNT-UHFFFAOYSA-N

Data: 124 KI 54 IC50 9 EC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 187 hits for monomerid = 50001859
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Bile salt export pump (Human)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	5.96E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Sigma non-opioid intracellular receptor 1 (Human)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	263	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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5-hydroxytryptamine receptor 1A (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	12.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
D(2) dopamine receptor (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	226	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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D(2) dopamine receptor (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	222	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	12.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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D(2) dopamine receptor (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	265	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2C (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-1/Beta-2/Beta-3 adrenergic receptor (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
D(1A) dopamine receptor (Bovine)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.70E+5	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
D(2) dopamine receptor (Bovine)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 1A (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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D(2) dopamine receptor (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 1A (Human)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 1A (Human)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	72	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 1A (Human)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	186	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 1A (Human)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	38	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 1A (Human)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Human)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	72	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Human)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	186	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Human)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Human)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Human)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	41	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	740	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F/2A/2B/2C/3A/3B/4/5A/5B/6/7 (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1B (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Bovine)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Bovine)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor (Bovine)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
D(2) dopamine receptor (Bovine)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
D(1A) dopamine receptor (Bovine)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
D(2) dopamine receptor (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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5-hydroxytryptamine receptor 2A (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
D(2) dopamine receptor (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
D(2) dopamine receptor (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium-dependent serotonin transporter (Rat)	BDBM50001859 (BUSPAR \| CHEMBL49 \| 8-[4-(4-Pyrimidin-2-yl-piperaz...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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