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BDBM50003372 CHEMBL308168::Hexyl-[4-(1-methyl-1,2,5,6-tetrahydro-pyridin-3-yl)-[1,2,5]thiadiazol-3-yl]-amine

SMILES: CCCCCCNc1nsnc1C1=CCCN(C)C1

InChI Key: InChIKey=QLVGAKONSDZSLC-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50003372   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50003372
PNG
(CHEMBL308168 | Hexyl-[4-(1-methyl-1,2,5,6-tetrahyd...)
Show SMILES CCCCCCNc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C14H24N4S/c1-3-4-5-6-9-15-14-13(16-19-17-14)12-8-7-10-18(2)11-12/h8H,3-7,9-11H2,1-2H3,(H,15,17)
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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 60n/an/an/an/an/an/a



Novo Nordisk CNS Division

Curated by ChEMBL


Assay Description
In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-oxotremorine-M (Oxo-M) as radioligand


J Med Chem 35: 2274-83 (1992)


Article DOI: 10.1021/jm00090a019
BindingDB Entry DOI: 10.7270/Q22J69TH
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50003372
PNG
(CHEMBL308168 | Hexyl-[4-(1-methyl-1,2,5,6-tetrahyd...)
Show SMILES CCCCCCNc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C14H24N4S/c1-3-4-5-6-9-15-14-13(16-19-17-14)12-8-7-10-18(2)11-12/h8H,3-7,9-11H2,1-2H3,(H,15,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 60n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat hippocampus M1 receptor using [3H]-oxotremorine-M (Oxo-M) as radioligand


J Med Chem 35: 4011-9 (1992)


Article DOI: 10.1021/jm00100a005
BindingDB Entry DOI: 10.7270/Q2KW5F1K
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50003372
PNG
(CHEMBL308168 | Hexyl-[4-(1-methyl-1,2,5,6-tetrahyd...)
Show SMILES CCCCCCNc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C14H24N4S/c1-3-4-5-6-9-15-14-13(16-19-17-14)12-8-7-10-18(2)11-12/h8H,3-7,9-11H2,1-2H3,(H,15,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 105n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat hippocampus M1 receptor using [3H]-pirenzepine (Pz) as radioligand


J Med Chem 35: 4011-9 (1992)


Article DOI: 10.1021/jm00100a005
BindingDB Entry DOI: 10.7270/Q2KW5F1K
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50003372
PNG
(CHEMBL308168 | Hexyl-[4-(1-methyl-1,2,5,6-tetrahyd...)
Show SMILES CCCCCCNc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C14H24N4S/c1-3-4-5-6-9-15-14-13(16-19-17-14)12-8-7-10-18(2)11-12/h8H,3-7,9-11H2,1-2H3,(H,15,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 60n/an/an/an/an/an/a



Novo Nordisk CNS Division

Curated by ChEMBL


Assay Description
In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-oxotremorine-M (Oxo-M) as radioligand


J Med Chem 35: 2274-83 (1992)


Article DOI: 10.1021/jm00090a019
BindingDB Entry DOI: 10.7270/Q22J69TH
More data for this
Ligand-Target Pair