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BDBM50003481 CHEMBL3215746::CHEMBL554052::Pyridin-3-yl-{4-[3-(3,4,5-trimethoxy-phenyl)-propionyl]-piperazin-1-yl}-acetonitrile; dihydrochloride; hydrate

SMILES: Cl.Cl.COc1cc(CCC(=O)N2CCN(CC2)C(C#N)c2cccnc2)cc(OC)c1OC

InChI Key: InChIKey=DLXPZNFSYVMESM-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50003481   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003481
PNG
(CHEMBL3215746 | CHEMBL554052 | Pyridin-3-yl-{4-[3-...)
Show SMILES Cl.Cl.COc1cc(CCC(=O)N2CCN(CC2)C(C#N)c2cccnc2)cc(OC)c1OC
Show InChI InChI=1S/C23H28N4O4/c1-29-20-13-17(14-21(30-2)23(20)31-3)6-7-22(28)27-11-9-26(10-12-27)19(15-24)18-5-4-8-25-16-18/h4-5,8,13-14,16,19H,6-7,9-12H2,1-3H3
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 400n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair