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BDBM50003482 CHEMBL132246::[4-(3,3-Diphenyl-propionyl)-piperazin-1-yl]-(3-nitro-phenyl)-acetonitrile

SMILES: [O-][N+](=O)c1cccc(c1)C(C#N)N1CCN(CC1)C(=O)CC(c1ccccc1)c1ccccc1

InChI Key: InChIKey=QPJUHAUBTBEASL-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50003482   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003482
PNG
(CHEMBL132246 | [4-(3,3-Diphenyl-propionyl)-piperaz...)
Show SMILES [O-][N+](=O)c1cccc(c1)C(C#N)N1CCN(CC1)C(=O)CC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H26N4O3/c28-20-26(23-12-7-13-24(18-23)31(33)34)29-14-16-30(17-15-29)27(32)19-25(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,18,25-26H,14-17,19H2
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.10E+4n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair